Regenerative Biology
Regenerative Biology is the Morgridge Institute's inaugural platform for realizing the institute’s discovery to delivery paradigm. In 2008, world-renowned stem cell pioneer and scientist Dr. James Thomson was appointed as its director and the first member of the Morgridge Institute’s multidisciplinary leadership team. This announcement signaled the institute’s commitment to recruiting world-class scientific talent to guide its mission of facilitating breakthrough research to improve human health.
Science; March 26, 2009
Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
“ . . . Here, we describe the derivation of human iPS cells using non-integrating episomal vectors. After removal of the episome, iPS cells completely free of vector and transgene sequences are derived that are similar to human embryonic stem (ES) cells in proliferative and developmental potential. These results demonstrate that reprogramming human somatic cells does not require genomic integration or the continued presence of exogenous reprogramming factors, and removes one obstacle to the clinical application of human iPS cells.”
